Detect Magic

Whenever you cast Detect Magic in the presence of an artifact (or you come into the presence of an artifact while Detect Magic is active), you are instantly and permanently blinded, as the Blindness/Deafness spell. Higher level detection spells (such as Arcane Sight and its Greater counterpart) are not susceptible to this rule.

Also, while Detect Magic is active, the caster’s eyes glow orange and red:
Detect magic

Detect Magic

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